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In humans, metabolism of many drugs is carried out by CYP3A, whereas in rats and dogs, CYP2C is a primary drug metabolism enzyme, as CYP3A levels in rats and dogs only reaches half the levels of their CYP2C activity

The interaction between these physiological effects and pre-existing medical vulnerabilities is critical

Baseline measurements were taken after an initial 5 min of incubation with coelenterazine-h or NanoGlo-containing PBS after which cells were then treated with either vehicle (PBS) or respective ligands

Intraoperative pulmonary aspiration (not on warning label) : This is the entry of liquid or solid material into the lungs during surgery as a result of delayed stomach emptying